O Programa de Mestrado em Ciências Farmacêuticas visa formar recursos humanos especializados em análises fitoquímicas, em estudos de atividade biológica (in vitro e in vivo), na pesquisa e desenvolvimento de ensaios analíticos, insumos, medicamentos e cosméticos, dirigindo sua atuação para a transformação da realidade, em benefício da sociedade.
Pesquisar este blog
segunda-feira, 26 de maio de 2014
VII Simpósio Iberoamericano de Plantas Medicinais (VII SIPM) e o II Simpósio Iberoamericano de Investigação em Câncer (II SIIC)
Temos a satisfação de comunicar que o VII Simpósio Iberoamericano de Plantas Medicinais (VII
SIPM) e o II Simpósio Iberoamericano de Investigação em Câncer (II SIIC)
com apoio do CYTED e CNPq serão realizados na cidade de Ilhéus - BA, no período
de 27 a 30 de outubro de 2014.
Os eventos são realizados
bianualmente, tendo iniciado em 2006 com a implantação da Rede Iberoamericana
de Estudos e Aproveitamento Sustentável da Biodiversidade Regional de Interesse
Farmacêutico (RIBIOFAR/CYTED/CNPq), gerando o Simpósio Iberoamericano de
Plantas Medicinais como atividade formativa da referida Rede.
Encontra-se em sua VII edição e está
sendo realizado em conjunto com o II Simpósio Iberoamericano de Investigação em
Câncer, que iniciou no ano de 2013 como atividade formativa de outra Rede do
CYTED/CNPq, denominada Red Iberoamericana De Investigación En Cáncer. De La
Genómica Al Control (RIBECANCER).
Ambos os eventos congregam cientistas
de diversas áreas de conhecimento (Farmacologia, Química, Botânica, Agronomia,
Farmácia, Medicina, Biodiversidade, Fitoterapia, Toxicologia, Políticas
Públicas, Governo, Setor Produtivo, etc.) que trabalham com plantas medicinais
e a biodiversidade como fonte de agentes com potencial terapêutico, incluindo o
câncer.
Mais de 5 mil pessoas já participaram
dos eventos anteriores. No ano de 2014, os eventos serão realizados em Ilhéus,
importante cidade turística da região sul da Bahia, visando ampliar a
participação de pesquisadores da região nordeste, visto a importância do tema e
a possibilidade de se ampliar as interações científicas e sociais.
Para
conhecer os detalhes da Rede RIBECANCER e palestras/resumos apresentados no I
SIIC-Campinas 2013 acesse o site www.ribecancer.com.br
Maiores
detalhes sobre os eventos de Ilhéus podem ser verificados no site http://www.iberoamericanopm2014.com/
Um
abraço e contamos com a participação e divulgação aos alunos, docentes,
pesquisadores e profissionais das áreas.
Profa. Simone Gualberto- UESB
Coordenadora do VII SIPM e II SIIC
Prof. Valdir Cechinel Filho-UNIVALI
Coordenador das Redes RIBIOFAR e
RIBECANCER.
terça-feira, 15 de abril de 2014
Concurso UNESP ARARAQUARA Química Farmacêutica e Medicinal
ADOS DO CONCURSO
Emprego Público: Professor Assistente Doutor
Campus: Araraquara
Unidade: Faculdade de Ciências Farmacêuticas
Departamento: Fármacos e Medicamentos
Quant. de vagas: 01 (uma)
Disciplinas: "Química Farmacêutica e
Medicinal".
Titulação: Doutorado
Regime de trabalho: RDIDP
Regime Jurídico: CLT
Data de início das Inscrições: 09/04/2014 Data de término
das Inscrições: 08/05/2014
Requisitos: graduados em curso de nível superior em
Farmácia ou Farmácia-Bioquímica, com titulação mínima de Doutor em Ciências
Farmacêuticas ou afins na área de Química Farmacêutica e/ou Medicinal.
Outras informações: Seção Técnica de Desenvolvimento e
Administração de Recursos Humanos - Rodovia Araraquara-Jaú, Km 01.
Contato: (16) 3301-6916
EDITAL
Nº Edital: 22/2014-DTAd-FCF/CAr.
Data de Publicação no DOE: 09/04/2014
Link para o Edital:
quinta-feira, 10 de abril de 2014
Concurso para professor de Farmacologia na UFSC
Professor
no Depto. de Farmacologia da UFSC.
Abaixo algumas
informações sobre o concurso:
Data da inscrição: até 29 de abril de 2014
Número de vagas: 01
Características da vaga: 40 h/DE
Data da inscrição: até 29 de abril de 2014
Número de vagas: 01
Características da vaga: 40 h/DE
Remuneração inicial: R$ 8.717,64
Concurso UNESP ARARAQUARA Química Farmacêutica e Medicinal
DADOS DO CONCURSO
Emprego Público: Professor Assistente Doutor
Campus: Araraquara
Unidade: Faculdade de Ciências Farmacêuticas
Departamento: Fármacos e Medicamentos
Quant. de vagas: 01 (uma)
Disciplinas: "Química Farmacêutica e
Medicinal".
Titulação: Doutorado
Regime de trabalho: RDIDP
Regime Jurídico: CLT
Data de início das Inscrições: 09/04/2014 Data de término
das Inscrições: 08/05/2014
Requisitos: graduados em curso de nível superior em
Farmácia ou Farmácia-Bioquímica, com titulação mínima de Doutor em Ciências
Farmacêuticas ou afins na área de Química Farmacêutica e/ou Medicinal.
Outras informações: Seção Técnica de Desenvolvimento e Administração
de Recursos Humanos - Rodovia Araraquara-Jaú, Km 01.
Contato: (16) 3301-6916
EDITAL
Nº Edital: 22/2014-DTAd-FCF/CAr.
Data de Publicação no DOE: 09/04/2014
Link para o Edital:
segunda-feira, 31 de março de 2014
quarta-feira, 26 de março de 2014
Sci. Pharm., Volume 82 (2014) Issue 1 published!
[If this
newsletter is not displaying correctly, please visit http://www.scipharm.at/newsletter/2014/1/]
We are delighted to announce the publication of Scientia Pharmaceutica (Sci Pharm) Volume 82 (2014), Issue 1. As before, all articles are published open-access and thus can be downloaded free of charge (no subscription needed) by clicking on the corresponding links at the end of this e-mail or by visiting www.scipharm.at/current. To facilitate reading through this table of contents, all research articles are assigned to one of the journal's four thematic sections: Pharmaceutical & Analytical Chemistry; Pharmacology & Clinical Pharmacy; Pharmacognosy & Phytocmedicine; Pharmaceutical Technology & Biopharmaceutics.
Manuscript Summary: November 1st 2013 to January
31st 2014
MS in hand in the beginning
of November: 55; MS received: 117; MS accepted: 16; MS rejected: 99; MS in hand
in the end of January: 57.
Once again, we are very thankful to our referees who ensure the high quality of those papers selected for publication.
Top and Hot from the Last Issue
Ranking of the most
popular articles from Issue 4 (2013) based on full-text downloads
(abstract-only-views are not included!) from www.scipharm.at (full-text
downloads from PubMed Central are not included) in January 2014:
I. 336 downloads for Afifi and Kasabri. Pharmacological and Phytochemical Appraisal of Selected Medicinal Plants from Jordan with Claimed Antidiabetic Activities. Sci Pharm. 2013; 81: 889–932. http://dx.doi.org/10.3797/scipharm.1212-20
II. 226 downloads for Sivakumar et al. Isolation and Characterisation of Degradation Impurities in the Cefazolin Sodium Drug Substance. Sci Pharm. 2013; 81: 933–950. http://dx.doi.org/10.3797/scipharm.1304-14
III. 212 downloads for Samanthula et al. Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Doxophylline and Terbutalinesulphate in Pharmaceutical Formulations. Sci Pharm. 2013; 81: 969–982. http://dx.doi.org/10.3797/scipharm.1305-14
IV. 194 downloads for Ali et al. Accelerated Stability Testing of a Clobetasol Propionate Loaded Nanoemulsion as per ICH Guideline. Sci. Pharm. 2013; 81: 1089–1100. http://dx.doi.org/10.3797/scipharm.1210-02
IV. 194 downloads for Roy and Chakrabarty et al. Development and Validation of a Stability-Indicating RP-HPLC Method for Simultaneous Determination of Phenoxyethanol, Methylparaben, Propylparaben, Mometasone Furoate, and Tazarotene in Topical Pharmaceutical Dosage Formulation. Sci Pharm. 2013; 81: 951–967. http://dx.doi.org/10.3797/scipharm.1303-22
Subscribe to the Print Edition or Recommend this
Journal to your Librarian
The print version
of Scientia Pharmaceutica can be ordered for Euro 210.- (+ 10% VAT +
postage) by email to office@scipharm.at.
German language clients may order directly at our publisher at verkauf@apoverlag.at
Advanced Online Publication of Coming Articles
Visit www.scipharm.at/inpress
to view accepted articles prior to publication in print.
On behalf of
Prof. Dr. Wolfgang Kubelka
Editor-in-Chief Scientia Pharmaceutica
Sci. Pharm.
Volume 82 (2014) | Issue 1
Original Papers and Short
Communications
Pharmaceutical & Analytical Chemistry
Regioselective
Synthesis, Characterization, and Antimicrobial Activities of Some New
Monosaccharide Derivatives
Sarkar M. A. Kawsar, Md O. Faruk, Mohammad S. Rahman, Yuki Fujii, Yasuhiro Ozeki
1–20
Details | Full Text (pdf) | Supporting Information (pdf, ca. 1.3 MB)
Biological Evaluation of Isoniazid Derivatives as An Anticancer Class
Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza
21–28
Details | Full Text (pdf)
Synthesis and Evaluation of [67Ga]-AMD3100: A Novel Imaging Agent for Targeting Chemokine Receptor CXCR4
Ayuob Aghanejad, Amir R. Jalilian, Yousef Fazaeli, Behrouz Alirezapoor, Mehraban Pouladi, Davoud Beiki, Stephan Maus, Ali Khalaj
29–42
Details | Full Text (pdf)
Isolation, Identification and Characterization of an Unknown Impurity in Lovastatin EP
Chandrakant Belwal, Praveen Kumar Goyal, Anup Balte, Sandeep Kolhe, Kamlesh Chauhan, Ajay Singh Rawat, Anand Vardhan
43–52
Details | Full Text (pdf)
Prediction of Pharmacokinetic Parameters Using Genetic Algorithm Combined with Artificial Neural Network for a Series of Alkaloid Drugs
Majid Zandkarimi, Mohammad Shafiei, Farzin Hadizadeh, Mohammad Ali Darbandi, Kaveh Tabrizian
53–70
Details | Full Text (pdf)
QSAR and Molecular Docking Studies of Oxadiazole-Ligated Pyrrole Derivatives as Enoyl-ACP (CoA) Reductase Inhibitors
Kalyani D. Asgaonkar, Ganesh D. Mote, Trupti S. Chitre
71–85
Details | Full Text (pdf)
Isolation and Evaluation of the Enantiospecific Antitubercular Activity of a Novel Triazole Compound
Radha Shekar, Barij Nayan Sinha, Arindam Mukhopadhya, Mariam S. Degani
87–97
Details | Full Text (pdf)
Development and Validation of a Stability-Indicating RP-HPLC Method for the Estimation of Drotaverine Impurities in API and Pharmaceutical Formulation
Veera Raghava Raju Thummala, Satya Sankarsana Jagan Mohan Tharlapu, Vijay Kumar Rekulapalli, Mrutyunjaya Rao Ivaturi, Someswara Rao Nittala
99–115
Details | Full Text (pdf)
Development and Validation of a Gas Chromatography Method for Trace Level Determination of Allylamine in Sevelamer Hydrochloride and Sevelamer Carbonate Drug Substances
Raju V. S. N. Kadiyala, Pavan Kumar S. R. Kothapalli, Madhava Reddy Peddolla, Pradeep Rajput, Hemant Kumar Sharma, Shankar Reddy Budeti, Himabindu Gandham, Annapurna Nowduri
117–128
Details | Full Text (pdf)
Pharmacology & Clinical Pharmacy
Evaluation of Serum
Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian
Breast Cancer Patients: Correlation with Clinico-Pathological Parameters
Yara A. Rashad, Tawfik R. Elkhodary, Amal M. El-Gayar, Laila A. Eissa
129–145
Details | Full Text (pdf)
Pharmacognosy & Phytomedicine
Cytotoxic
Sesquiterpene Lactones from Kauna lasiophthalma Griseb
Eliana M. Maldonado, Daniel Svensson, Stina M. Oredsson, Olov Sterner
147–160
Details | Full Text (pdf) | Supporting Information (pdf, ca. 0.1 MB)
Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats
Tahira Perveen, Saida Haider, Nudrat Anwar Zuberi, Sadia Saleem, Sana Sadaf, Zehra Batool
161–170
Details | Full Text (pdf)
HPLC Analysis and Cytotoxicity of n-Butanol Extract from Glyphaea brevis Roots Against C6 Glioma Cells
Koffi Marcel Konan, Janat Akhanovna Mamyrbekova-Bekro, Norbert Bakalara, David Virieux, Jean-Luc Pirat, Yves-Alain Bekro
171–176
Details | Full Text (pdf)
Pharmaceutical Technology & Biopharmaceutics
Dissolution
Improvement of Atorvastatin Calcium Using Modified Locust Bean Gum by the Solid
Dispersion Technique
Dharmila Panghal, Manju Nagpal, Gurjeet Singh Thakur, Sandeep Arora
177–191
Details | Full Text (pdf)
Lectin-Grafted PLGA Microcarriers Loaded with Fluorescent Model Drugs: Characteristics, Release Profiles, and Cytoadhesion Studies
Xue-Yan Wang, Romana Koller, Michael Wirth, Franz Gabor
193–205
Details | Full Text (pdf)
Instructions for
Authors 2014
207–218
Full Text (pdf)
Sci Pharm – the peer
reviewed journal of pharmaceutical sciences from Austria – publishes original
research papers, short communications and a limited number of reviews on all
fields of the pharmaceutical sciences and related areas, as well as on
pharmaceutical practice.
Information for Authors and a manuscript template can be accessed on www.scipharm.at/authors
Sci Pharm is indexed/abstracted by (in alphabetical order): Academic Search Complete (EBSCO Publishing); Asian Science Citation Index (ASCI Database); CAB Abstracts (Centre for Agricultural Bioscience International); Chemical Abstracts (American Chemical Society); Chimica (Elsevier); Derwent Biotechnology Abstracts (Thomson Scientific); Derwent Drug File (Thomson Scientific); Directory of Open Access Journals (DOAJ); EMBASE/excerpta medica (Elsevier); Global Health (Centre for Agricultural Bioscience International); Google Scholar (Google); Hinari (World Health Organization); History of Science, Technology, and Medicine (Research Libraries Group); Index Copernicus (Index Copernicus Ltd.); International Pharmaceutical Abstracts (Thomson Scientific); Mass Spectrometry Bulletin (Royal Society of Chemistry); Master Journal List (Thomson Reuters); Medicinal and Aromatic Plants Abstracts (Scientific Publishers); Methods in Organic Synthesis (Royal Society of Chemistry); Natural Product Updates (Royal Society of Chemistry); Open J-Gate (Informatics Ltd); ProQuest Health & Medical Complete (Cambridge Information Group); ProQuest Pharma Collection (Cambridge Information Group); Scopus (Elsevier); VINITI (All-Russian Institute of Scientific and Technical Information of the Russian Academy of Science).
Issue 2 (Vol 82) will be officially released on June 30th, 2014!
Sincerely,
Dr. Gernot A. Eller
Managing Editor Scientia Pharmaceutica
office@scipharm.at | www.scipharm.at
We are delighted to announce the publication of Scientia Pharmaceutica (Sci Pharm) Volume 82 (2014), Issue 1. As before, all articles are published open-access and thus can be downloaded free of charge (no subscription needed) by clicking on the corresponding links at the end of this e-mail or by visiting www.scipharm.at/current. To facilitate reading through this table of contents, all research articles are assigned to one of the journal's four thematic sections: Pharmaceutical & Analytical Chemistry; Pharmacology & Clinical Pharmacy; Pharmacognosy & Phytocmedicine; Pharmaceutical Technology & Biopharmaceutics.
Manuscript Summary: November 1st 2013 to January
31st 2014
MS in hand in the beginning
of November: 55; MS received: 117; MS accepted: 16; MS rejected: 99; MS in hand
in the end of January: 57. Once again, we are very thankful to our referees who ensure the high quality of those papers selected for publication.
Top and Hot from the Last Issue
Ranking of the most
popular articles from Issue 4 (2013) based on full-text downloads
(abstract-only-views are not included!) from www.scipharm.at (full-text
downloads from PubMed Central are not included) in January 2014: I. 336 downloads for Afifi and Kasabri. Pharmacological and Phytochemical Appraisal of Selected Medicinal Plants from Jordan with Claimed Antidiabetic Activities. Sci Pharm. 2013; 81: 889–932. http://dx.doi.org/10.3797/scipharm.1212-20
II. 226 downloads for Sivakumar et al. Isolation and Characterisation of Degradation Impurities in the Cefazolin Sodium Drug Substance. Sci Pharm. 2013; 81: 933–950. http://dx.doi.org/10.3797/scipharm.1304-14
III. 212 downloads for Samanthula et al. Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Doxophylline and Terbutalinesulphate in Pharmaceutical Formulations. Sci Pharm. 2013; 81: 969–982. http://dx.doi.org/10.3797/scipharm.1305-14
IV. 194 downloads for Ali et al. Accelerated Stability Testing of a Clobetasol Propionate Loaded Nanoemulsion as per ICH Guideline. Sci. Pharm. 2013; 81: 1089–1100. http://dx.doi.org/10.3797/scipharm.1210-02
IV. 194 downloads for Roy and Chakrabarty et al. Development and Validation of a Stability-Indicating RP-HPLC Method for Simultaneous Determination of Phenoxyethanol, Methylparaben, Propylparaben, Mometasone Furoate, and Tazarotene in Topical Pharmaceutical Dosage Formulation. Sci Pharm. 2013; 81: 951–967. http://dx.doi.org/10.3797/scipharm.1303-22
Subscribe to the Print Edition or Recommend this
Journal to your Librarian
The print version
of Scientia Pharmaceutica can be ordered for Euro 210.- (+ 10% VAT +
postage) by email to office@scipharm.at.
German language clients may order directly at our publisher at verkauf@apoverlag.at
Advanced Online Publication of Coming Articles
Visit www.scipharm.at/inpress
to view accepted articles prior to publication in print. Prof. Dr. Wolfgang Kubelka
Editor-in-Chief Scientia Pharmaceutica
Sci. Pharm.
Volume 82 (2014) | Issue 1
Original Papers and Short
Communications
Pharmaceutical & Analytical Chemistry
Regioselective
Synthesis, Characterization, and Antimicrobial Activities of Some New
Monosaccharide Derivatives Sarkar M. A. Kawsar, Md O. Faruk, Mohammad S. Rahman, Yuki Fujii, Yasuhiro Ozeki
1–20
Details | Full Text (pdf) | Supporting Information (pdf, ca. 1.3 MB)
Biological Evaluation of Isoniazid Derivatives as An Anticancer Class
Felipe A. R. Rodrigues, Augusto C. A. Oliveira, Bruno C. Cavalcanti, Claudia Pessoa, Alessandra C. Pinheiro, Marcus V. N. de Souza
21–28
Details | Full Text (pdf)
Synthesis and Evaluation of [67Ga]-AMD3100: A Novel Imaging Agent for Targeting Chemokine Receptor CXCR4
Ayuob Aghanejad, Amir R. Jalilian, Yousef Fazaeli, Behrouz Alirezapoor, Mehraban Pouladi, Davoud Beiki, Stephan Maus, Ali Khalaj
29–42
Details | Full Text (pdf)
Isolation, Identification and Characterization of an Unknown Impurity in Lovastatin EP
Chandrakant Belwal, Praveen Kumar Goyal, Anup Balte, Sandeep Kolhe, Kamlesh Chauhan, Ajay Singh Rawat, Anand Vardhan
43–52
Details | Full Text (pdf)
Prediction of Pharmacokinetic Parameters Using Genetic Algorithm Combined with Artificial Neural Network for a Series of Alkaloid Drugs
Majid Zandkarimi, Mohammad Shafiei, Farzin Hadizadeh, Mohammad Ali Darbandi, Kaveh Tabrizian
53–70
Details | Full Text (pdf)
QSAR and Molecular Docking Studies of Oxadiazole-Ligated Pyrrole Derivatives as Enoyl-ACP (CoA) Reductase Inhibitors
Kalyani D. Asgaonkar, Ganesh D. Mote, Trupti S. Chitre
71–85
Details | Full Text (pdf)
Isolation and Evaluation of the Enantiospecific Antitubercular Activity of a Novel Triazole Compound
Radha Shekar, Barij Nayan Sinha, Arindam Mukhopadhya, Mariam S. Degani
87–97
Details | Full Text (pdf)
Development and Validation of a Stability-Indicating RP-HPLC Method for the Estimation of Drotaverine Impurities in API and Pharmaceutical Formulation
Veera Raghava Raju Thummala, Satya Sankarsana Jagan Mohan Tharlapu, Vijay Kumar Rekulapalli, Mrutyunjaya Rao Ivaturi, Someswara Rao Nittala
99–115
Details | Full Text (pdf)
Development and Validation of a Gas Chromatography Method for Trace Level Determination of Allylamine in Sevelamer Hydrochloride and Sevelamer Carbonate Drug Substances
Raju V. S. N. Kadiyala, Pavan Kumar S. R. Kothapalli, Madhava Reddy Peddolla, Pradeep Rajput, Hemant Kumar Sharma, Shankar Reddy Budeti, Himabindu Gandham, Annapurna Nowduri
117–128
Details | Full Text (pdf)
Pharmacology & Clinical Pharmacy
Evaluation of Serum
Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian
Breast Cancer Patients: Correlation with Clinico-Pathological Parameters Yara A. Rashad, Tawfik R. Elkhodary, Amal M. El-Gayar, Laila A. Eissa
129–145
Details | Full Text (pdf)
Pharmacognosy & Phytomedicine
Cytotoxic
Sesquiterpene Lactones from Kauna lasiophthalma Griseb Eliana M. Maldonado, Daniel Svensson, Stina M. Oredsson, Olov Sterner
147–160
Details | Full Text (pdf) | Supporting Information (pdf, ca. 0.1 MB)
Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats
Tahira Perveen, Saida Haider, Nudrat Anwar Zuberi, Sadia Saleem, Sana Sadaf, Zehra Batool
161–170
Details | Full Text (pdf)
HPLC Analysis and Cytotoxicity of n-Butanol Extract from Glyphaea brevis Roots Against C6 Glioma Cells
Koffi Marcel Konan, Janat Akhanovna Mamyrbekova-Bekro, Norbert Bakalara, David Virieux, Jean-Luc Pirat, Yves-Alain Bekro
171–176
Details | Full Text (pdf)
Pharmaceutical Technology & Biopharmaceutics
Dissolution
Improvement of Atorvastatin Calcium Using Modified Locust Bean Gum by the Solid
Dispersion Technique Dharmila Panghal, Manju Nagpal, Gurjeet Singh Thakur, Sandeep Arora
177–191
Details | Full Text (pdf)
Lectin-Grafted PLGA Microcarriers Loaded with Fluorescent Model Drugs: Characteristics, Release Profiles, and Cytoadhesion Studies
Xue-Yan Wang, Romana Koller, Michael Wirth, Franz Gabor
193–205
Details | Full Text (pdf)
207–218
Full Text (pdf)
Information for Authors and a manuscript template can be accessed on www.scipharm.at/authors
Sci Pharm is indexed/abstracted by (in alphabetical order): Academic Search Complete (EBSCO Publishing); Asian Science Citation Index (ASCI Database); CAB Abstracts (Centre for Agricultural Bioscience International); Chemical Abstracts (American Chemical Society); Chimica (Elsevier); Derwent Biotechnology Abstracts (Thomson Scientific); Derwent Drug File (Thomson Scientific); Directory of Open Access Journals (DOAJ); EMBASE/excerpta medica (Elsevier); Global Health (Centre for Agricultural Bioscience International); Google Scholar (Google); Hinari (World Health Organization); History of Science, Technology, and Medicine (Research Libraries Group); Index Copernicus (Index Copernicus Ltd.); International Pharmaceutical Abstracts (Thomson Scientific); Mass Spectrometry Bulletin (Royal Society of Chemistry); Master Journal List (Thomson Reuters); Medicinal and Aromatic Plants Abstracts (Scientific Publishers); Methods in Organic Synthesis (Royal Society of Chemistry); Natural Product Updates (Royal Society of Chemistry); Open J-Gate (Informatics Ltd); ProQuest Health & Medical Complete (Cambridge Information Group); ProQuest Pharma Collection (Cambridge Information Group); Scopus (Elsevier); VINITI (All-Russian Institute of Scientific and Technical Information of the Russian Academy of Science).
Issue 2 (Vol 82) will be officially released on June 30th, 2014!
Sincerely,
Dr. Gernot A. Eller
Managing Editor Scientia Pharmaceutica
office@scipharm.at | www.scipharm.at
quinta-feira, 20 de março de 2014
Aniversariantes do Mês de Março
MARÇO
|
|
Marcia Maria de Souza
|
06/mar
|
Vera Lúcia Lângaro Amaral
|
11/mar
|
Marlova Manhabosco Dal Molin
|
19/mar
|
Tania Mari Bellé Bresolin
|
25/mar
|
Thaisa Baccarin
|
27/mar
|
Concurso na UFPB, Centro de Biotecnologia (CBiotec).
Concurso na UFPB, Centro de Biotecnologia (CBiotec).
Vagas: Nanociências (1) e Fisiologia Vegetal (1)
Informações: (83) 3216-7173
e.mail: valdir@cbiotec.ufpb.br
DOU No 32, sexta feira, 14 de fevereiro 2014.
Vagas: Nanociências (1) e Fisiologia Vegetal (1)
Informações: (83) 3216-7173
e.mail: valdir@cbiotec.ufpb.br
DOU No 32, sexta feira, 14 de fevereiro 2014.
Prêmio Henri Nestlé
Prêmio Henri Nestlé
11 3145-0406
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Chamada Artigos Congresso Epidemiologia
Prezados Coordenadores,
Venho por meio deste informar que a Revista Brasileira de Pesquisa
em Saúde(RBPS) está recebendo manuscritos para compor o número
temático do IX
Congresso Brasileiro de Epidemiologia: As fronteiras da epidemiologia
contemporânea: do conhecimento científico à ação.
Uma parceria realizada entre a Revista Brasileira de Pesquisa em
Saúde (RBPS) e a Equipe Organizadora da Associação Brasileira de Saúde Coletiva
(ABRASCO) pretende disponibilizar no evento, em setembro de 2014, um número da
RBPS dedicado ao congresso.
Trata-se de uma oportunidade única para alunos de iniciação
científica, especializandos e doutorandos publicarem seus trabalhos em revista
nacional indexada. Visto que muitos programas de pós-graduação tem exigido a
publicação de artigos como pré-requisito de ingresso a cursos de vários níveis.
Pensando nisso, a ABRASCO Jovem pretende fomentar a participação
dos estudantes no IX
Congresso Brasileiro de Epidemiologia(http://www.epiabrasco.com.br/abrasco-jovem.html)
Solicito encarecidamente que encaminhem este e-mail aos possíveis
interessados.
O prazo para submissão de artigos será 30/03/2014 pelo site da RBPS: (http://periodicos.ufes.br/RBPS/index)
O prazo para submissão de artigos será 30/03/2014 pelo site da RBPS: (http://periodicos.ufes.br/RBPS/index)
Edson Theodoro dos Santos Neto
Editor Científico - Revista Brasileira de Pesquisa em Saúde
sexta-feira, 14 de fevereiro de 2014
Planta Medica Issue 2/3 is now available
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Dear Colleague, This Newsletter highlights a joint Planta Medica issue combining issues 2 and 3. I would like to focus on a review, a pharmacological study, and a natural product chemistry paper. In their review Wölfe et al. cover the topical applications of St. John's wort (Hypericum perforatum). This herb is one of the most prominent and best investigated medicinal plants of the last decades, mainly because of its antidepressant activity. From the beginning, however, traditional use was also characterized by external applications, mainly in the form of oils and tinctures, e.g. as a treatment for burns. |
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In Mexico, the combination of medicinal herbs and pharmaceutical drugs is a common practice; unfortunately, there is little scientific evidence for the pharmacological interactions between natural products and drugs. Déciga-Campos et al. have combined ursolic acid, a pentacyclic triterpene isolated from various plant species used for their analgesic properties, with diclofenac (a non-steroidal anti-inflammatory drug) and tramadol (an agonist opioid drug), in order to evaluate their antinociceptive synergistic interactions. Pancreatic cancer is one of the most deadly forms of cancer associated with the lowest 5-year survival rates known for cancers. Pancreatic cancers are hypovascular in nature resulting in an inadequate supply of nutrition and oxygen to aggressively proliferating cells. However, pancreatic cancer cells show an extraordinary tolerance to starvation enabling them to survive in hypovascular (austerity) conditions. Development of drugs aimed at countering this tolerance to nutrient starvation is a novel antiausterity approach in anticancer drug discovery. Mai Thanh Thi Nguyen et al. have screened a series of medicinal plants for antiausterity activity, using the PANC-1 human pancreatic cancer cell line. Some geranyl dihydrochalcones from Artocarpus altilis were identified as potent antitumoural candidates. It is my pleasure to offer you free access to these publications! Sincerely yours, Luc Pieters Planta Medica, Editor-in-Chief |
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CONTENTS
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Topical Application of St.
John's Wort (Hypericum perforatum) (FREE ACCESS)
Ute Wölfle, Günter Seelinger, Christoph M. Schempp |
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St.
John's wort (Hypericum
perforatum) has been intensively investigated for its
antidepressive activity, but dermatological applications also have a long
tradition. Topical St. John's wort preparations such as oils or tinctures are
used for the treatment of minor wounds and burns, sunburns, abrasions,
bruises, contusions, ulcers, myalgia, and many others. Pharmacological
research supports the use in these fields. Of the constituents,
naphthodianthrones (e.g., hypericin) and phloroglucinols (e.g., hyperforin)
have interesting pharmacological profiles, including antioxidant,
anti-inflammatory, anticancer, and antimicrobial activities.
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In
addition, hyperforin stimulates growth and differentiation of keratinocytes,
and hypericin is a photosensitizer which can be used for selective treatment
of non-melanoma skin cancer. However, clinical research in this field is
still scarce. Recently, sporadic trials have been conducted in wound healing,
atopic dermatitis, psoriasis, and herpes simplex infections, partly with
purified single constituents and modern dermatological formulations. St.
John's wort also has a potential for use in medical skin care. Composition
and stability of pharmaceutical formulations vary greatly depending on origin
of the plant material, production method, lipophilicity of solvents, and
storage conditions, and this must be regarded with respect to practical as
well as scientific purposes. Read more
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Isobolographic Analysis of
the Antinociceptive Interaction between Ursolic Acid and Diclofenac or
Tramadol in Mice (FREE ACCESS)
Myrna Déciga-Campos, Alejandra Cortés, Francisco Pellicer, Irene Díaz-Reval, María Eva González-Trujano |
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It
is considered that natural products used in folk medicine can potentiate the
effect of drugs. The aim of this study was to evaluate the pharmacological
interaction between ursolic acid, a triterpene isolated from herbal medicines
to treat pain, and the analgesics diclofenac or tramadol. Individual
dose-response curves of the antinociceptive effect of these compounds were
built to calculate the ED50, as well as the pharmacological
interaction, by using isobolographic analysis. All treatments decreased
significantly and in a dose-dependent manner the writhing behavior with ED50
values of 103.50 ± 19.66, 20.54 ± 6.05, and 9.60 ± 1.69mg/kg, for ursolic
acid, diclofenac, and tramadol, respectively.
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An
isobolographic analysis allowed the characterization of the pharmacological
interaction produced by a fixed ratio combination of 1:1 and 1:3 of
equi-effective doses of these compounds. Theoretical antinociceptive ED50
values of ursolic acid–diclofenac were 62.12 ± 10.28 and 41.43 ± 6.69 mg/kg,
respectively, not statistically different from those obtained experimentally
(44.52 ± 5.25 and 44.89 ± 49.05 mg/kg, respectively), reporting an additive
interaction. Theoretical antinociceptive ED50 values of ursolic
acid-tramadol (56.56 ± 9.87 and 33.08 ± 5.07 mg/kg, respectively) were
significantly lower than those observed experimentally (138.36 ± 49.05 and
67.34 ± 18.98 mg/kg, respectively) reporting antagonism in this interaction.
Antinociceptive response obtained from isobolograms in the writhing test was
corroborated by using formalin test in mice. Adverse effects such as gastric
damage in the ursolic acid-diclofenac combination did not increase in an
additive form similarly as with antinociception. Conversely, sedative
response was significantly increased in the ursolic acid-tramadol
combination. As observed in the formalin test, the antagonism on the
antinociceptive response between ursolic acid and tramadol (1:1) was not reverted
in the presence of the opioid antagonist naltrexone (1mg/kg, i. p.). These
results provide evidence for a differential pharmacological interaction, in
which ursolic acid does not interfere with the antinociceptive effect of
diclofenac but antagonizes that obtained with tramadol in an independent
opioid mechanism. Therefore, medicinal plants containing abundant presence of
ursolic acid may also modify efficacy in the alternative combinations for
pain therapy. Read more
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Geranyl Dihydrochalcones
from Artocarpus altilis and Their Antiausteric Activity (FREE ACCESS)
Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Khang Duy Huu Nguyen, Hien Thu Thi Dau, Hai Xuan Nguyen, Phu Hoang Dang, Tam Minh Le, Trong Huu Nguyen Phan, Anh Hai Tran, Bac Duy Nguyen, Jun-ya Ueda, Suresh Awale |
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Human
pancreatic cancer cell lines have remarkable tolerance to nutrition
starvation, which enables them to survive under a tumor microenvironment. The
search for agents that preferentially inhibit the survival of cancer cells
under low nutrient conditions is a novel antiausterity strategy in anticancer
drug discovery.
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In
this study, the methanolic extract of the leaves of Artocarpus altilis showed
100% preferential cytotoxicity against PANC-1 human pancreatic cancer cells
under nutrient-deprived conditions at a concentration of 50 μg/mL. Further
investigation of this extract led to the isolation of eight new geranylated
dihydrochalcones named sakenins A-H together with four known compounds. Among
them, sakenins F and H were identified as potent preferentially cytotoxic
candidates with PC50 values of 8.0 μM and 11.1 μM, respectively. Read more
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Table of Contents: Issues 2 and 3,
February 2014
Reviews Topical Application of St. Johnʼs Wort (Hypericum perforatum) Ute Wölfle, Günter Seelinger, Christoph M. Schempp Abstract | HTML | PDF Biological and Pharmacological Activity Original Papers The Ethanol Extract of Lonicera japonica (Japanese Honeysuckle) Attenuates Diabetic Nephropathy by Inhibiting p-38 MAPK Activity in Streptozotocin-Induced Diabetic Rats Thing-Fong Tzeng, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu Abstract | HTML | PDF The Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-ß-D-Glucoside on Pressure Overload-Induced Cardiac Remodeling in Rats and Its Possible Mechanism Xiao Le Xu, Qiu Yan Zhu, Cheng Zhao, Fei Wang, Zhong Yin Zhou, Ya E Hu, Wei Zhang Abstract | HTML | PDF Isobolographic Analysis of the Antinociceptive Interaction between Ursolic Acid and Diclofenac or Tramadol in Mice Myrna Déciga-Campos, Alejandra Cortés, Francisco Pellicer, Irene Díaz-Reval, María Eva González-Trujano Abstract | HTML | PDF The Total Phenolic Fraction of Anemarrhena asphodeloides Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity Wenjun Zhao, Meng Wang, Lu Shao, Min Liao, Kang Liu, Fang Huang, Baolin Liu Abstract | HTML | PDF The Inhibitory Effect of Scutellaria baicalensis Extract and Its Active Compound, Baicalin, on the Translocation of the Androgen Receptor with Implications for Preventing Androgenetic Alopecia Ah-Reum Kim, Su-Na Kim, In-Keun Jung, Hyun-Hee Kim, Young-Ho Park, Won-Seok Park Abstract | HTML | PDF Ferulic Acid Enhances the Chemical and Biological Properties of Astragali Radix: A Stimulator for Danggui Buxue Tang, An Ancient Chinese Herbal Decoction Ken Y. Z. Zheng, Zhen X. Zhang, Crystal Y. Q. Du, Wendy L. Zhang, Cathy W. C. Bi, Roy C. Y. Choi, Tina T. X. Dong, Karl W. K. Tsim Abstract | HTML | PDF Acaricidal Activities against House Dust Mites of Spearmint Oil and Its Constituents Ji-Yeon Yang, Min-Gi Kim, Sung-Eun Lee, Hoi-Seon Lee Abstract | HTML | PDF Inhibition of Hepatitis C Virus Replication In Vitro by Xanthohumol, A Natural Product Present in Hops Sai Lou, Yi-Min Zheng, Shan-Lu Liu, Jianming Qiu, Qunying Han, Na Li, Qianqian Zhu, Pingping Zhang, Cuiling Yang, Zhengwen Liu Abstract | HTML | PDF Kaempferol Derivatives as Antiviral Drugs against the 3a Channel Protein of Coronavirus Silvia Schwarz, Daniel Sauter, Kai Wang, Ronghua Zhang, Bing Sun, Anastasia Karioti, Anna Rita Bilia, Thomas Efferth, Wolfgang Schwarz Abstract | HTML | PDF Letters In Vitro and In Vivo Studies of Trypanocidal Activity of Dietary Isothiocyanates Dietmar Steverding, Sarah Michaels, Kevin D. Read Abstract | HTML | PDF Pharmacokinetic Investigations Original Papers Pharmacokinetic Interaction of Astragaloside IV with Atractylenolide I and Prim-O-Glucosylcimifugin in Male Sprague Dawley Rats Jue Song, Shi-rui Zheng, Yong Jin, Jun Li Abstract | HTML | PDF Natural Product Chemistry Original Papers Geranyl Dihydrochalcones from Artocarpus altilis and Their Antiausteric Activity Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Khang Duy Huu Nguyen, Hien Thu Thi Dau, Hai Xuan Nguyen, Phu Hoang Dang, Tam Minh Le, Trong Huu Nguyen Phan, Anh Hai Tran, Bac Duy Nguyen, Jun-ya Ueda, Suresh Awale Abstract | HTML | PDF Xanthones from Swertia mussotii and Their α-Glycosidase Inhibitory Activities Cui-Ting Luo, Huan-huan Zheng, Shuang-Shuang Mao, Mao-xun Yang, Cheng Luo, Heru Chen Abstract | HTML | PDF Sphaeralcic Acid and Tomentin, Anti-inflammatory Compounds Produced in Cell Suspension Cultures of Sphaeralcea angustifolia Juanita Pérez-Hernández, Manasés González-Cortazar, Silvia Marquina, Maribel Herrera-Ruiz, Mariana Meckes-Fischer, Jaime Tortoriello, Francisco Cruz-Sosa, María del Pilar Nicasio-Torres Abstract | HTML | PDF Hepatoprotective Triterpenoids and Saponins of Schefflera kwangsiensis Yan Wang, Chun-Lei Zhang, Yan-Fei Liu, Dong Liang, Huan Luo, Zhi-You Hao, Ruo-Yun Chen, De-Quan Yu Abstract | HTML | PDF Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana Gui-Guang Cheng, Xiang-Hai Cai, Bao-Hong Zhang, Yan Li, Ji Gu, Mei-Fen Bao, Ya-Ping Liu, Xiao-Dong Luo Abstract | HTML | PDF Letters Diterpene Alkaloids from the Roots of Aconitum moldavicum and Assessment of Nav 1.2 Sodium Channel Activity of Aconitum Alkaloids Botond Borcsa, László Fodor, Dezsõ Csupor, Peter Forgo, Attila Molnár V., Judit Hohmann Abstract | HTML | PDF Analytical Studies Original Papers Simultaneous Determination of Five Minor Coumarins and Flavonoids in Glycyrrhiza uralensis by Solid-Phase Extraction and High-Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Xue Qiao, Chun-Fang Liu, Shuai Ji, Xiong-Hao Lin, De-An Guo, Min Ye Abstract | HTML | PDF Fast Quantification of S-adenosyl-L-methionine in Dietary Health Products Utilizing Reversed-Phase High-performance Liquid Chromatography: Teaching an Old Method New Tricks Jing-Ru Liou, Li-Yeh Chuang, Yuan-Han Yang, Tung-Ying Wu, Mohamed El-Shazly, Shyh-Jong Wu, Tusty-Jiuan Hsieh, Yang-Chang Wu, Jiumn-Yih Wu, Fang-Rong Chang Abstract | HTML | PDF Click here to see the full table of contents for this issue.
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