O Programa de Mestrado em Ciências Farmacêuticas visa formar recursos humanos especializados em análises fitoquímicas, em estudos de atividade biológica (in vitro e in vivo), na pesquisa e desenvolvimento de ensaios analíticos, insumos, medicamentos e cosméticos, dirigindo sua atuação para a transformação da realidade, em benefício da sociedade.
JULHO
|
|
| José Roberto Bresolin | 01/jul |
| Ednéia Casagranda Bueno | 02/jul |
| Angela Cristina de Carli Petreanu | 11/jul |
| Cristiani Bürger | 13/jul |
| Marta Ferreira da Silva Marcondes | 15/jul |
| Fábio Lazzarotto de Oliveira | 15/jul |
| Bruna Proiss Fenner da Costa | 19/jul |
| Silmara Mendes Hoepers | 31/jul |
|
 |
 |
Dear Colleague, Welcome to the 9th issue of the Planta Medica Newsletter 2013! In this Planta Medica issue I have selected a review, a pharmacological and an analytical study to be highlighted. Harlev et al. have reviewed natural products originating from plants of the Cactaceae family with cancer preventive or curative properties, a still largely unexploited area of research. Hot flushes are the most common and distressing symptom accompanying the menopausal transition in women; finding an alternative treatment is of importance as increasing numbers of women become reluctant to rely on classical hormone replacement therapy. Rahte et al. have investigated the mechanism of action and the active principles of Salvia officinalis against hot flushes. It is suggested that common and ubiquitous estrogenic flavonoids are involved in its anti-hot flush effect. |
  |
Finally, Zeng et
al. have developed and validated a quantitative liquid
chromatography–electrospray ionization–mass spectrometric method for the
simultaneous determination of 18 bioactive constituents in Tripterygium wilfordii,
which is widely distributed in southern China. The stem and root of T. wilfordii, known as
"Leigongteng" (in Chinese "thunder god vine"), are used
in traditional Chinese medicine, and play a significant role in the clinical
treatment of rheumatoid arthritis in China.
It is my pleasure to offer you free access to these publications! |
Sincerely,  Luc Pieters Planta Medica, Editor-in-Chief |
CONTENTS
|
Cancer Preventive and
Curative Attributes of Plants of the Cactaceae Family: A
Review
(FREE ACCESS) Eli Harlev, Eviatar Nevo, Elaine Solowey, Anupam Bishayee |
 |
The
ever-increasing occurrence of cancer and the severe side effects and limited
efficacy of current cancer chemotherapy based on chemical drugs shift the
attention toward drugs of plant origin.
The Cactaceae family comprises more than 1500 species, but until recently only a few of them have been tested for their chemopreventive and anticancer attributes, leaving a wide unexplored area still waiting for researchers to be investigated. |
Considering
this fact, and also the promising results obtained with the relatively few
plants of this family already tested, it should justly be expected that some
plants of the Cactaceae
family yet unexplored might possess outstanding anticancer attributes,
exceeding those displayed by the plants already tested.
This review presents in vitro and in vivo experimental evidence on cancer chemopreventive and therapeutic potential of bioactive phytoconstituents and extracts derived from cactus plants. It also examines the underlying biochemical and molecular mechanisms involved in the antineoplastic effects of plants of the Cactaceae family. Current limitation and future directions of research towards effective use of cacti to develop efficient and side effect-free future cancer-preventive and anticancer drugs are also discussed. Read more |
Salvia officinalis for Hot Flushes: Towards Determination of Mechanism of
Activity and Active Principles (FREE ACCESS)
Sinikka Rahte, Richard Evans, Philippe J. Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemir |
 |
Herbal
medicinal products are commonly used in alternative treatment of menopausal
hot flushes. In a recent clinical study, Salvia
officinalis tincture was found to reduce hot flush frequency and
intensity.
The aim of the current study was the investigation of the mechanism(s) responsible for the anti-hot flush activity of S. officinalis and determination of its active principle(s). The 66% ethanolic tincture, as well as the n-hexane, CHCl3, and aqueous ethanolic subextracts obtained from the |
tincture
were studied in vitro
for two of the most relevant activities, estrogenicity and selective
serotonin reuptake inhibition. Because of an increased risk of menopausal
women to suffer from Alzheimer's disease, an in vitro acetylcholinesterase inhibition
assay was also employed. No activity was observed in the selective serotonin
reuptake inhibition or the acetylcholinesterase inhibition assays at the
highest test concentrations. The tincture showed no estrogenic effects whereas
the aqueous ethanolic subextract exhibited estrogenicity in the ERLUX assay
with an EC50 value of 64 µg/mL. Estrogenic activity-guided
fractionation of the aqueous ethanolic subextract by a combination of
reverse-phase vacuum liquid chromatography and gel chromatography identified
luteolin-7-O-glucuronide (EC50 129 µg/mL) as the active component
of the vacuum liquid chromatography fraction 4 (EC50 69 µg/mL).
Luteolin-7-O-glucoside was identified as the putative estrogenic principle of
the most potent minor fraction (EC50 0.7 µg/mL) obtained from the
initial vacuum liquid chromatography fraction 7 (EC50 3 µg/mL).
This study suggests the involvement of common and ubiquitous estrogenic
flavonoids in the anti-hot flush effect of Salvia
officinalis, a safe and commonly used herbal medicinal product
during the menopause. Read more
|
Simultaneous Quantification
of 18 Bioactive Constituents in Tripterygium wilfordii Using Liquid Chromatography-Electrospray Ionization-Mass
Spectrometry (FREE ACCESS)
Feng Zeng, Wei Wang, Shuhong Guan, Chunru Cheng, Min Yang, Bharathi Avula, Ikhlas A. Khan, De-an Guo |
 |
A
liquid chromatography – electrospray ionization – mass spectrometry method
with multiple reaction monitoring was established for simultaneous
quantification of 18 bioactive constituents from the stem and root of Tripterygium wilfordii
Hook. f. collected from different places in China and various commercial
preparations.
|
The
chromatographic separations were achieved on an Agilent Poroshell SB–C18
column (150 × 4.6 mm, 3.5 µm) with gradient elution using acetonitrile and 0.03%
formic acid aqueous solution in 45 min. Detection was performed in the
positive ionization mode by monitoring the precursor–product combination. The
validation of the method included tests of linearity, sensitivity, precision,
repeatability, stability, and accuracy. All calibration curves showed good
linearity (r > 0.9990) within the test range. The established method
showed good precision and accuracy with intraday and interday variations of
2–5% and 1–4%, respectively, and recoveries of 95.5–104.5%. Read more
|
Table of Contents: Issue 9, June
2013
Reviews Original Papers FREE ARTICLE: Cancer Preventive and Curative Attributes of Plants of the Cactaceae Family: A Review Eli Harlev, Eviatar Nevo, Elaine Solowey, Anupam Bishayee Abstract | HTML | PDF Biological and Pharmacological Activity Original Papers Anxiolytic Action of Pterostilbene: Involvement of Hippocampal ERK Phosphorylation Md. Al Rahim, Agnes M. Rimando Kalpten Silistreli, Abir T. El-Alfy Abstract | HTML | PDF Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects Wei-ping Zhang, Xiao-jun Bai, Xiao-pu Zheng, Xiao-lu Xie, Zu-yi Yuan Abstract | HTML | PDF Wound-Healing Potential of the Root Extract of Albizzia lebbeck Apurva Joshi, Nidhi Sengar, Satyendra K. Prasad, Raj Kumar Goel, Akanksha Singh, Siva Hemalatha Abstract | HTML | PDF Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-Induced Cardiac Damage in Mice Jian-ping Zhang, Yuan-yuan Zhang, Ying Zhang, Yong-gang Gao, Juan-juan Ma, Na Wang, Jiang-yan Wang, Yun Xie, Feng-hua Zhang, Li Chu Abstract | HTML | PDF FREE ARTICLE: Salvia officinalis for Hot Flushes: Towards Determination of Mechanism of Activity and Active Principles Sinikka Rahte, Richard Evans, Philippe J. Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemir Abstract | HTML | PDF Hepatoprotective Phenolic Glycosides from Gymnema tingens Jin Tian, Qin-Ge Ma, Jian-Bo Yang, Ai-Guo Wang, Teng-Fei Ji, Yan-Gai Wang, Ya-Lun Su Abstract | HTML | PDF Protective Effects of α-Tocopherol and Ascorbic Acid against Cardol-Induced Cell Death and Reactive Oxygen Species Generation in Staphylococcus aureus Wakae Murata, Toshio Tanaka, Isao Kubo, Ken-ichi Fujita Abstract | HTML | PDF Arsenic Trioxide-Enhanced, Matrine-Induced Apoptosis in Multiple Myeloma Cell Lines Qinghong Yu, Binhai Chen, Xiang Zhang, WenBin Qian, Baodong Ye, Yuhong Zhou Abstract | HTML | PDF Inhibition of Lipopolysaccharide-Induced iNOS and COX-2 Expression by Indole Alkaloid, 3-(Hydroxymethyl)-6,7-Dihydroindolo[2,3-a]Quinolizin-(12H)-one, via NF-κB Inactivation in RAW 264.7 Macrophages Feng Zhao, Lei Chen, Menglin Zhang, Chenchen Bi, Lichun Li, Qingzhen Zhang, Cuicui Shi, Miao Li, Songsong Zhou, Linghua Kong Abstract | HTML | PDF Natural Product Chemistry Letters Steroidal Glycosides from Reineckia carnea herba and Their Antitussive Activity Na Han, Ling Li Chen, Yao Wang, Rui Xue, Li Bo Zou, Fang Liu, Jun Yin Abstract | HTML | PDF Three New Xanthones from the Resin of Garcinia hanburyi Yun-Xia Deng, Tao Guo, Zhi-Yu Shao, Hui Xie, Sheng-Li Pan Abstract | HTML | PDF Analytical Studies Original Papers FREE ARTICLE: Simultaneous Quantification of 18 Bioactive Constituents in Tripterygium wilfordii Using Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Feng Zeng, Wei Wang, Shuhong Guan, Chunru Cheng, Min Yang, Bharathi Avula, Ikhlas A. Khan, De-an Guo Abstract | HTML | PDF Click here to see the full table of contents for this issue.
|
||||||||||
|
|
A comparative study
on anticoagulant activities of three Chinese herbal medicines from the genus Panax
and anticoagulant activities of ginsenosides Rg1 and Rg2
|
|
|
C.
T. Li, H.
B. Wang, and B.
J. Xu
|
|
|
Pharmaceutical
Biology , Early Online: 1-4.
Summary | Full Text | PDF (176 KB) | PDF Plus (177 KB) |
|
|
Different
extraction pretreatments significantly change the flavonoid contents of Scutellaria
baicalensis
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-8.
Summary | Full Text | PDF (617 KB) | PDF Plus (618 KB) |
|
|
Phenylpropanoids
from Podocarpium podocarpum
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-5.
Summary | Full Text | PDF (189 KB) | PDF Plus (190 KB) |
|
|
Herbal medicinal
oils in traditional Persian medicine
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-11.
Summary | Full Text | PDF (722 KB) | PDF Plus (723 KB) |
|
|
In vivo analgesic and
anti-inflammatory activities of Rosmarinus officinalis aqueous
extracts, rosmarinic acid and its acetyl ester derivative
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-4.
Summary | Full Text | PDF (146 KB) | PDF Plus (147 KB) |
|
|
Brine shrimp
lethality assay ‘an effective prescreen’: Microwave-assisted synthesis, BSL
toxicity and 3DQSAR studies-based designing, docking and antitumor evaluation
of potent chalcones
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-13.
Summary | Full Text | PDF (413 KB) | PDF Plus (413 KB) |
|
|
Cytotoxic
withanolides from the leaves of Moroccan Withania frutescens
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-7.
Summary | Full Text | PDF (262 KB) | PDF Plus (263 KB) |
|
|
Increased
production of plumbagin in Plumbago indica root cultures by gamma ray
irradiation
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-5.
Summary | Full Text | PDF (259 KB) | PDF Plus (260 KB) |
|
|
Protective effect
of artichoke (Cynara scolymus) leaf extract against lead toxicity in
rat
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-6.
Summary | Full Text | PDF (238 KB) | PDF Plus (239 KB) |
|
|
Antimutagenic
properties of affinin isolated from Heliopsis longipes extract
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-5.
Summary | Full Text | PDF (203 KB) | PDF Plus (203 KB) |
|
|
Ejaculatory
activities of Allanblackia floribunda stem bark in spinal male rats
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-7.
Summary | Full Text | PDF (386 KB) | PDF Plus (387 KB) |
|
|
Syringic acid from Tamarix
aucheriana possesses antimitogenic and chemo-sensitizing activities in
human colorectal cancer cells
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-15.
Summary | Full Text | PDF (1370 KB) | PDF Plus (1371 KB) |
|
|
ABCB1-overexpressing
MG63/DOX cell xenograft model: Maintain the MDR phenotype in vivo
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-6.
Summary | Full Text | PDF (464 KB) | PDF Plus (465 KB) |
|
|
Methanol extract of
the aerial parts of barley (Hordeum vulgare) suppresses
lipopolysaccharide-induced inflammatory responses in vitro and in
vivo
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-11.
Summary | Full Text | PDF (599 KB) | PDF Plus (600 KB) | Supplemental Material |
|
|
An in vitro model
for spontaneous angiogenesis using rat mesenteric endothelial cells: Possible
therapeutic perspective for obesity and related disorders
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-7.
Summary | Full Text | PDF (567 KB) | PDF Plus (568 KB) |
|
|
Novel GHB-derived
natural products from European mistletoe (Viscum album)
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-6.
Summary | Full Text | PDF (258 KB) | PDF Plus (259 KB) |
|
|
Antioxidant
activity of different parts of Tetrataenium lasiopetalum
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-5.
Summary | Full Text | PDF (228 KB) | PDF Plus (229 KB) |
|
|
Antinociceptive
activity and pathway of the pallanalgesin isolated from venom of Agkistrodon
halys (Pallas)
|
|
|
Yong
Ye, Mingyang
Li, and Xuelan
Chen
|
|
|
Pharmaceutical
Biology , Early Online: 1-10.
Summary | Full Text | PDF (368 KB) | PDF Plus (368 KB) |
|
|
Saponin and
non-saponin fractions of red ginseng ameliorate cisplatin-induced pica in rats
|
|
|
|
|
|
Pharmaceutical
Biology , Early Online: 1-9.
Summary | Full Text | PDF (463 KB) | PDF Plus (464 KB) |
|
Technology Partner - Atypon
Systems, Inc.
|
 |
