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Dear Colleague,
Planta Medica
issue 5 contains the abstracts of the 12th Annual Oxford
International Conference on the Science of Botanicals (ICSB, April 15Gingerol: A Novel AT1 Antagonist for the Treatment of Cardiovascular Disease Qing Liu, Jinjin Liu, Haili Guo, Shengnan Sun, Shifeng Wang, Yanling Zhang, Shiyou Li, Yanjiang Qiao Abstract | HTML | PDF
Letters FREE ARTICLE: Sarothrin from Alkanna orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor Jessica R. Bame, Tyler N. Graf, Hiyas A. Junio, R. Owen Bussey III, Scott A. Jarmusch, Tamam El-Elimat, Joseph O. Falkinham III, Nicholas H. Oberlies, Richard A. Cech, Nadja B. Cech Abstract | HTML | PDF
FREE ARTICLE: Antileishmanial Activity of 5-Methyl-2,2' : 5',2"-terthiophene Isolated from Porophyllum ruderale is Related to Mitochondrial Dysfunction in Leishmania amazonensis Helena Teru Takahashi, Elizandra Aparecida Britta, Renata Longhini, Tânia Ueda-Nakamura, João Carlos Palazzo de Mello, Celso Vataru Nakamura Abstract | HTML | PDF
Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda Virginie Esters, Charles Karangwa, Monique Tits, Pierre Francotte, Bernard Pirotte, Anne-Catherine Servais, Marianne Fillet, Jacques Crommen, Elmar Robbrecht, Arlette Minet, Thierry Grisar, Luc Angenot, Michel Frederich Abstract | HTML | PDF
Natural Product Chemistry
Original Papers Sesquineolignans and Terpene-Sesquineolignans: Anti-Acetylcholinesterase Constituents from Illicium simonsiith–18th,
2013, University of Mississippi, University, MS, USA). Nevertheless a
reduced number of regular contributions are included as well.
Cardiovascular diseases are associated with high morbidity, mortality, and
financial burden to health care services.
In their search for novel compounds targeting the angiotensin II type 1
receptor, accepted as a therapeutic target in cardiovascular disease, Liu et al. have
characterised [6]-gingerol from Zingiber
officinale (ginger) as a novel antagonist of this receptor.
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Botanicals have been suggested as an under-utilized source of
antimicrobial agents. Bame et
al. have identified the flavonoid sarothrin from Alkanna orientalis
as an antimicrobial agent and efflux pump inhibitor.
Leishmaniasis is a group of diseases caused by protozoa parasites of the
genus Leishmania.
The drugs used in leishmaniasis treatment present several problems,
including high toxicity and many adverse effects, and there is a high need
for new and better therapeutic agents.
Takahashi et al.
have reported that the antileishmanial activity of
5-methyl-2,2':5',2"-terthiophene isolated from Porophyllum ruderale
is related to mitochondrial dysfunction in Leishmania amazonensis.
It is my pleasure to offer you free access to these publications.
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Sincerely,
Luc Pieters
Planta Medica,
Editor-in-Chief
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Considering
the prevalence of cardiovascular disease in public health and the limited
validated therapeutic options, this study aimed to find novel compounds
targeting the angiotensin II type 1 receptor, accepted as a therapeutic
target in cardiovascular disease.
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A
small library consisting of 89 compounds from 39 Chinese herbs was profiled
using a cell-based calcium mobilization assay which was developed and
characterized for high-throughput screening. [6]-Gingerol from Zingiber officinale
Roscoe (ginger) was identified as a novel angiotensin II type 1 receptor
antagonist, with an IC50 value of 8.173 μM. The hit was further
tested by a specificity assay indicating that it had no antagonistic
effects on other evaluated GPCRs, such as endothelin receptors. The major
ingredient of ginger, [6]-gingerol, could inhibit angiotensin II type 1
receptor activation, which partially clarified the mechanism of ginger
regulating blood pressure and strengthening heart in the cardiovascular
system. Read more
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An
Alkanna orientalis
leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that
causes an estimated 478,000 hospitalizations in the US annually.
Bioassay-guided fractionation of A.
orientalis resulted in isolation of the flavonoid sarothrin
(5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), which inhibited the growth of Mycobacterium smegmatis
(MIC 75 μM) and S.
aureus (MIC > 800 μM), and possessed efflux pump inhibitory
activity.
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This
is the first report of antimicrobial or efflux pump inhibitory activity of
sarothrin, and of its presence in A.
orientalis. These findings suggest that the effectiveness of
A. orientalis
extracts is due to a combination of multiple constituents, including
sarothrin. Read more
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Recently,
this research group isolated 5-methyl-2,2':5',2"-terthiophene
(compound A) and 5'-methyl–[5–(4–acetoxy-1–butynyl)]–2,2'-bi-thiophene
(compound B) from the aerial parts of Porophyllum
ruderale, and reported their antiproliferative activity in
promastigotes and axenic amastigote forms of Leishmania amazonensis. Here it was
demonstrated that both compounds exhibited activity against intracellular
amastigotes showing IC50 values of 37 and 51 μg/mL for compounds
A and B, respectively.
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Both
compounds showed low levels of toxicity for human cells, even at the
highest concentrations (hemolytic index < 10% at 500 μg/mL).
Promastigotes treated with compound A showed an alteration in the
mitochondrial membrane when observed by flow cytometry through labeling
with rhodamine 123 and this was confirmed by transmission electron
microscopy. Alterations on morphology (rounded cells) were observed by
scanning electron microscopy in parasites treated with the compounds.
Further studies should be performed employing compounds A and B for the
development of new drugs for chemotherapy of leishmaniasis. Read more
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Table of Contents: Issue Issue 5,
March 2013
Biological and
Pharmacological Activity
Original Papers
Neuroprotection of a
Novel Synthetic Caffeic Acid-Syringic Acid Hybrid Compound against
Experimentally Induced Transient Cerebral Ischemic Damage
In Hye Kim, Bing Chun Yan, Joon Ha Park, Go Heum Yeun, Yongbae Yim, Ji
Hyeon Ahn, Jae-Chul Lee, In Koo Hwang, Jun Hwi Cho, Young-Myeong Kim, Yun
Lyul Lee, Jeong Ho Park, Moo-Ho Won
Abstract | HTML | PDF
FREE ARTICLE: [6]-
Chuanfu Dong, Lei Liu, Xiaonian Li, Zhengye Guan, Huairong Luo, Yifen Wang
Abstract | HTML | PDF
New Flavonol and
Diterpenoids from the Endophytic Fungus Aspergillus sp. YXf3
Tong Yan, Zhi Kai Guo, Rong Jiang, Wei Wei, Ting Wang, Ye Guo, Yong Chun
Song, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge
Abstract | HTML | PDF
Cytotoxic Triterpenoid
Saponins from the Stems of Gordonia longicarpa
Jia Tang, Lei Yu, Huizheng Fu, Chuangjun Li, Jingzhi Yang, Wanqi Zhou,
Xiaoguang Chen, Dongming Zhang
Abstract | HTML | PDF
Letters
Phenolic Constituents
from the Twigs of Euonymus alatus and Their Cytotoxic and Anti-inflammatory
Activity
Ki Hyun Kim, Sang Keun Ha, Sang Un Choi, Sun Yeou Kim, Kang Ro Lee
Abstract | HTML | PDF
Cytotoxic Pentacyclic
Triterpenoids from Prinsepia utilis
Bin Guan, Cheng-Cheng Peng, Qi Zeng, Xiang-Rong Cheng, Shi-Kai Yan, Hui-Zi
Jin, Wei-Dong Zhang
Abstract | HTML | PDF
Click here to see
the full table of contents for this issue.
About
this Journal
Editor in Chief: Luc Pieters, Belgium
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Planta Medica is one of the leading
international journals in the field of medicinal plants and natural
products with original research papers, letters, rapid communications,
reviews, minireviews and perspectives from researchers worldwide.
Authors, please
submit your manuscripts electronically to: http://mc.manuscriptcentral.com/plamed.
For further information about Planta
Medica, please visit www.thieme.de/plantamedica
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©
Thieme Medical Publishers, Inc. 2008-2013, All Rights Reserved
333 7th Ave., New York, NY
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