Acta Pharmacologica Sinica - Table of Contents alert Volume 35 Issue 2

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TABLE OF CONTENTS Volume 35, Issue 2 (February 2014) In this issue Review Original Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Special issue on Christopher Walsh - an innovator in antibiotic chemistry The January 2014 special issue of The Journal of Antibiotics features Christopher Walsh, an innovator in antibiotic chemistry, and brings together not only a review from Walsh himself, expertly pointing us in the direction of new antibiotics, but also many contributions from his colleagues. FREE access to select articles today!  Review Top EZH2: biology, disease, and structure-based drug discovery OPEN Jin-zhi Tan, Yan Yan, Xiao-xi Wang, Yi Jiang and H Eric Xu Acta Pharmacol Sin 2014 35: 161-174; advance online publication, December 23, 2013; 10.1038/aps.2013.161 Abstract | Full Text Original Articles Top Co-activation of nAChR and mGluR induces γ oscillation in rat medial septum diagonal band of Broca slices Ya-li Wang, Jian-gang Wang, Gao-xiang Ou-yang, Xiao-li Li, Zaineb Henderson and Cheng-biao Lu Acta Pharmacol Sin 2014 35: 175-184; advance online publication, January 6, 2014; 10.1038/aps.2013.138 Abstract | Full Text Glutamate microinjection into the hypothalamic paraventricular nucleus attenuates ulcerative colitis in rats Ting-ting Li, Jian-fu Zhang, Su-juan Fei, Sheng-ping Zhu, Jin-zhou Zhu, Xiao Qiao and Zhang-bo Liu Acta Pharmacol Sin 2014 35: 185-194; advance online publication, December 23, 2013; 10.1038/aps.2013.140 Abstract | Full Text Exendin-4 ameliorates oxidized-LDL-induced inhibition of macrophage migration in vitro via the NF-κB pathway Ge-fei Ma, Song Chen, Lei Yin, Xiang-dong Gao and Wen-bing Yao Acta Pharmacol Sin 2014 35: 195-202; advance online publication, December 16, 2013; 10.1038/aps.2013.128 Abstract | Full Text Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation Long-gang He, Xiang-lian Li, Xiang-zhou Zeng, Heng Duan, Song Wang, Lin-sheng Lei, Xiao-juan Li and Shu-wen Liu Acta Pharmacol Sin 2014 35: 203-210; advance online publication, December 23, 2013; 10.1038/aps.2013.139 Abstract | Full Text Daptomycin exerts rapid bactericidal activity against Bacillus anthracis without disrupting membrane integrity Yu-hua Xing, Wei Wang, Su-qin Dai, Ti-yan Liu, Jun-jie Tan, Guo-long Qu, Yu-xia Li, Yan Ling, Gang Liu, Xue-qi Fu and Hui-peng Chen Acta Pharmacol Sin 2014 35: 211-218; advance online publication, December 23, 2013; 10.1038/aps.2013.159 Abstract | Full Text Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response Shi-jun He, Ze-min Lin, Yan-wei Wu, Bing-xin Bai, Xiao-qian Yang, Pei-lan He, Feng-hua Zhu, Wei Tang and Jian-ping Zuo Acta Pharmacol Sin 2014 35: 219-229; advance online publication, December 30, 2013; 10.1038/aps.2013.167 Abstract | Full Text Microvesicles secreted from human multiple myeloma cells promote angiogenesis Yan Liu, Xiao-jian Zhu, Chen Zeng, Pin-hui Wu, Hong-xiang Wang, Zhi-chao Chen and Qiu-bai Li Acta Pharmacol Sin 2014 35: 230-238; advance online publication, December 30, 2013; 10.1038/aps.2013.141 Abstract | Full Text Inhibition of EGFR autophosphorylation plays an important role in the anti-breast cancer efficacy of the dithiocarbamate derivative TM208 Xi-wei Ji, Run-tao Li, Zai-quan Li, Liang Li, Xue-yan Shao, Si-yuan Wang, Yin Yuan, Tian-yan Zhou and Wei Lu Acta Pharmacol Sin 2014 35: 239-247; advance online publication, December 30, 2013; 10.1038/aps.2013.156 Abstract | Full Text Antitumor effects of concanavalin A and Sophora flavescens lectin in vitro and in vivo Zheng Shi, Jie Chen, Chun-yang Li, Na An, Zi-jie Wang, Shu-lin Yang, Kai-feng Huang and Jin-ku Bao Acta Pharmacol Sin 2014 35: 248-256; advance online publication, December 23, 2013; 10.1038/aps.2013.151 Abstract | Full Text Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro: a novel Nrf2 activator without a “dark side” Ben-ping Zhang, Jie Zhao, Shan-shan Li, Li-jing Yang, Ling-lan Zeng, Yan Chen and Jun Fang Acta Pharmacol Sin 2014 35: 257-266; advance online publication, December 30, 2013; 10.1038/aps.2013.165 Abstract | Full Text S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro Ya-si Xu, Jian-guo Feng, Dan Zhang, Bo Zhang, Min Luo, Dan Su and Neng-ming Lin Acta Pharmacol Sin 2014 35: 267-274; advance online publication, December 23, 2013; 10.1038/aps.2013.176 Abstract | Full Text Bioavailability, tissue distribution, and excretion characteristics of the novel carbonic anhydrase inhibitor tolsultazolamide in rats Jin-da Wang, Yong-ping Shi, Jing Yin, Zhi-yuan Pan, Wen-yu Cui, Yan-fang Zhang and Hai Wang Acta Pharmacol Sin 2014 35: 275-282; advance online publication, December 16, 2013; 10.1038/aps.2013.146 Abstract | Full Text Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models Yu-hua Li, Hui-chang Bi, Ling Huang, Jing Jin, Guo-ping Zhong, Xu-nian Zhou and Min Huang Acta Pharmacol Sin 2014 35: 283-291; advance online publication, December 23, 2013; 10.1038/aps.2013.157 Abstract | Full Text Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice Jun Yao, Cheng-gang Li, Li-kun Gong, Chen-chen Feng, Chun-zhu Li, Man Gao, Yang Luan, Xin-ming Qi and Jin Ren Acta Pharmacol Sin 2014 35: 292-300; advance online publication, December 23, 2013; 10.1038/aps.2013.145 Abstract | Full Text Structure-based ensemble-QSAR model: a novel approach to the study of the EGFR tyrosine kinase and its inhibitors Xian-qiang Sun, Lei Chen, Yao-zong Li, Wei-hua Li, Gui-xia Liu, Yao-quan Tu and Yun Tang Acta Pharmacol Sin 2014 35: 301-310; advance online publication, December 16, 2013; 10.1038/aps.2013.148 Abstract | Full Text Advertisement Your submitted manuscript needs to make a good first impression. Nature Publishing Group Language Editing service focuses on improving your written English. So it?s your results that stand out, not your grammar. Save 10% by entering code LE_NAT14. Upload your manuscript today! http://languageediting.nature.com  Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Eye. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. 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Divulgação concursos

Divulgação Concurso Fiocruz 2014

http://portal.fiocruz.br/pt-br/content/concurso-fiocruz-2014-editais-serao-publicados-na-proxima-quarta-feita-241

Divulgação de  concurso para Farmacêutico - Concurso público para Farmacêutico no Ministério da Agricultura, Pecuária e Abastecimento - MAPA

Edital completo; http://pfarma.com.br/concurso-farmaceutico/1578-concurso-para-farmaceutico-no-mapa.html

Divulgação de concurso na UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REI

http://www.ufsj.edu.br/portal2-repositorio/File/secop/2013/EDITAIS/CPD%20143%20BIOQUIMICA%20efetivo%20DCNAT.pdf

Journal of Natural Products Welcomes A New Associate Editor

Welcome Dr. Swanson from the University of Illinois

Journal of Natural Products Welcomes New Associate Editor Editor-in-Chief A. Douglas Kinghorn and the Associate Editors of Journal of Natural Products welcome Dr. Steven M. Swanson, Professor at the University of Illinois, as a new Associate Editor. Dr. Swanson's research focuses on biological testing on natural products using molecular, cell based and in vivo model systems with the goal of discovering novel anticancer agents. View Selected Publications Authored by Dr. Swanson Bioactive Constituents of Indigofera spicata Lynette Bueno Pérez, Jie Li, Daniel D. Lantvit, Li Pan, Tran Ngoc Ninh, Hee-Byung Chai, Djaja Djendoel Soejarto, Steven M. Swanson, David M. Lucas, and A. Douglas Kinghorn DOI: 10.1021/np400567c Isolation, Structure Elucidation, and Biological Evaluation of 16,23-Epoxycucurbitacin Constituents from Eleaocarpus chinensis Li Pan, Yeonjoong Yong, Ye Deng, Daniel D. Lantvit, Tran Ngoc Ninh, Heebyung Chai, Esperanza J. Carcache de Blanco, Djaja D. Soejarto, Steven M. Swanson, and A. Douglas Kinghorn DOI: 10.1021/np200879p Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320) Arlene A. Sy-Cordero, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies DOI: 10.1021/np2004243 Minutissamides A-D, Antiproliferative Cyclic Decapeptides from the Cultured Cyanobacterium Anabaena minutissima Hahk-Soo Kang , Aleksej Krunic , Qi Shen , Steven M. Swanson , and Jimmy Orjala DOI: 10.1021/np2002226

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Pós-doutores em empresas

Empresas recrutam pós-doutores para inovar

26/01/2014 - 03h00 

DHIEGO MAIA
DE SÃO PAULO

Assim que concluiu o mais alto nível de especialização em uma universidade da Espanha, a pós-doutora em biologia molecular Ana Azambuja, 32, fez o caminho inverso de grande parte de seus colegas: em vez do mundo acadêmico, ela escolheu um trabalho na indústria.

"Eu tinha uma agonia em ver anos de pesquisa na universidade não sendo aplicados. Na indústria, o processo é mais rápido e palpável."

A pesquisadora trabalha no centro de pesquisas da Natura, na Grande São Paulo. Ela desenvolve estudos para retardar o envelhecimento da pele, a maior demanda da companhia.

A partir de março, ela vai integrar uma pesquisa que vai consumir R$ 20 milhões pelos próximos dez anos para investigar todos os fatores que levam o ser humano à sensação de bem-estar.

Azambuja faz parte de um seleto grupo de pesquisadores que desenvolve inovação na iniciativa privada.

Segundo a mais recente pesquisa de Inovação Tecnológica do IBGE (Instituto Brasileiro de Geografia e Estatística), a falta de mão de obra qualificada é o segundo maior obstáculo à inovação na indústria brasileira.

O primeiro é o custo elevado.

O presidente do Centro de Gestão e Estudos Estratégicos (CGEE), Mariano Laplane, explica que a presença de "pós-docs" nas grandes corporações é um fenômeno novo.

"Esse processo ainda está emergindo no Brasil. A maior parte das pesquisas ainda é feita nas universidades, até pela quantidade de doutores que o país dispõe."

	Eduardo Anizelli/Folhapress
	Ana Azambuja é pesquisadora da Natura. Ela diz que, no mercado, a pesquisa é mais palpável

Em Belém do Pará, outro pós-doutor mantém em paralelo as atividades acadêmicas com a pesquisa no mercado.

Cleidison de Souza, 39, trabalha no instituto de tecnologia da Vale.

Especialista da área de computação, ele desenvolve um software para reduzir os índices de acidentes de trabalho nos trilhos entre Carajás (PA) e São Luís (MA), trecho utilizado pela companhia para o transporte de minério de ferro.

Ele diz que a "fuga" de pós-doutores rumo ao mercado ocorre pela remuneração.

"O salário do professor universitário não é adequado dado o papel desse profissional. Isso influencia a ida dele para a indústria."

O pós-doutorado não é um título acadêmico, mas a parte prática da pesquisa.

Em geral, tem um ano de duração. Ainda não se sabe a quantidade certa de pós-doutores que circula pelo país.

Só a Capes (autarquia do governo responsável pela pós-graduação) forneceu em 2013, mais de 6,1 mil benefícios para o pós-doutorado.

A Fapesp (Fundação de Amparo à Pesquisa do Estado de São Paulo) também é outra entidade que apoia a formação de "pós-docs".

Em seis anos, a fundação concedeu mais de 8.000 bolsas.

VI SINPOSPq - VI Simpósio Internacional de Pós-graduação e Pesquisa

A Comissão Organizadora do VI Simpósio Internacional de Pós-graduação e Pesquisa tem o prazer de convidá-lo (a) a participar da 6º edição do evento, que será realizado em Ribeirão Preto, de 16 a 19 de Setembro de 2014.

As inscrições e a submissão de resumos estarão disponíveis a partir de Fevereiro de 2014.

Mais informações através do site http://www.sinpospq.org/
           Twitter https://twitter.com/sinpospq
           Facebook https://www.facebook.com/sinpospq2014     
           Contato sinpospq@fcfrp.usp.br
 

Contamos com a sua presença em 2014.
 
Atenciosamente,
Comissão Organizadora do VI SINPOSPq.

Indian J Pharm Sci - New issue online

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Table of Contents - Indian Journal of Pharmaceutical Sciences (Indian J Pharm Sci)
2013 | November-December | Volume 75 | Issue 6

RESEARCH PAPERS

Sustained release of diltiazem hydrochloride from cross-linked biodegradable IPN hydrogel beads of pectin and modified xanthan gum [pg. 619]
TK Giri, C Choudhary, A Alexander, Ajazuddin , H Badwaik, M Tripathy, DK Tripathi
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Pharmacognostic standardisation and antiproliferative activity of aegle marmelos (L.) Correa leaves in various human cancer cell lines [pg. 628]
Rajbir Bhatti, J Singh, AK Saxena, Nitasha Suri, M. P. S. Ishar
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Therapeutic effects of policosanol and atorvastatin against global brain ischaemia-reperfusion injury in gerbils [pg. 635]
V Molina, Y Ravelo, M Noa, R Mas, Y Pérez, A Oyarzábal, N Mendoza, M Valle, S Jiménez, J Sánchez
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Hepatoprotective and antioxidant activity of dunaliella salina in paracetamol-induced acute toxicity in rats [pg. 642]
Fedekar F Madkour, MM Abdel-Daim
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Antioxidant and anticholinesterase activities in various parts of sonneratia caseolaris (L.) [pg. 649]
P Wetwitayaklung, C Limmatvapirat, T Phaechamud
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Neuroprotective activity of pongamia pinnata in monosodium glutamate-induced neurotoxicity in rats [pg. 657]
A. H. M. Viswanatha Swamy, NL Patel, PC Gadad, BC Koti, UM Patel, A. H. M. Thippeswamy, DV Manjula
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Mosla punctulata inhibits mast cell-mediated allergic reactions through the inhibition of histamine release and inflammatory cytokine production [pg. 664]
IG Je, TY Shin, SH Kim
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Validated HPLC method for the determination of paclitaxel-related substances in an intravenous emulsion loaded with a paclitaxel-cholesterol complex [pg. 672]
XJ Xia, J Peng, PX Zhang, DJ Jin, YL Liu
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

2D QSAR study for gemfibrozil glucuronide as the mechanism-based inhibitor of CYP2C8 [pg. 680]
N Taxak, PV Bharatam
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Antifungal treatments delineate a correlation between cathepsins and cytokines in murine model of invasive aspergillosis [pg. 688]
Ashwani Mittal, Anjum Gahlaut, GL Sharma, R Dabur
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Effect of mechanical properties on the release of meloxicam from poloxamer gel bases [pg. 700]
O Inal, E Algin Yapar
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Gemcitabine hydrochloride-loaded functionalised carbon nanotubes as potential carriers for tumour targeting [pg. 707]
Shilpee Das, Jagruti L Desai, Hetal P Thakkar
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Development and validation of a hptlc method for simultaneous estimation of L-glutamic acid and γ-aminobutyric acid in mice brain [pg. 716]
JS Sancheti, MF Shaikh, PF Khatwani, Savita R Kulkarni, Sadhana Sathaye
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

SHORT COMMUNICATIONS

Montmorillonite Poly-L-lactide microcomposites of procainamide for controlled drug delivery: In vitro and in vivo evaluation [pg. 722]
BB Kevadiya, TK Patel, Parvati B Patel, Shalini Rajkumar, CB Tripathi, HC Bajaj
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Effect of hydrophilic diluents on the release profile of griseofulvin from tablet formulations [pg. 726]
O. N. C. Umeh, JC Azegba, SI Ofoefule
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Fluorimetric quantification of brimonidine tartrate in eye drops [pg. 730]
G Sunitha, R Bhagirath, VR Alapati, K Ramakrishna, C. V. S Subrahmanyam, PD Anumolu
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Antibacterial activity of rhizome of curcuma aromatica and partial purification of active compounds [pg. 732]
S Revathi, NS Malathy
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

Development and validation of an RP-HPLC method for quantitative estimation of eslicarbazepine acetate in bulk drug and tablets [pg. 736]
M Singh, L Kumar, P Arora, SC Mathur, PK Saini, RM Singh, GN Singh
[ABSTRACT]   [HTML FULL TEXT]   [PDF]   [Mobile HTML Full text ]   [EPub]

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