Prezado(a) pesquisador(a),

 

O Portal de Periódicos, da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), oferece acesso às mais importantes publicações científicas produzidas no mundo. A partir de quatro tipos de busca – assunto, periódico, livro e base de dados – você pode explorar o universo de informações disponíveis nas diversas áreas do conhecimento para desenvolver e aperfeiçoar sua pesquisa científica.

 

Além de democratizar e facilitar o acesso à ciência mundial, o Portal de Periódicos possui papel fundamental como política de Estado, estimulando as pesquisas no país e contribuindo para a internacionalização da ciência brasileira, o que tem contribuído para uma maior participação do Brasil no ranking da produção científica internacional. Dessa forma, tanto os pesquisadores quanto suas pesquisas ganham maior visibilidade.

 

Por se tratar de uma biblioteca virtual, o Portal de Periódicos pode ser acessado por acesso remoto ou a partir de qualquer computador localizado nas mais de 420 instituições de ensino e pesquisa brasileiras. Essas instituições possuem acesso gratuito ao conteúdo de alta qualidade assinado junto às principais Editoras e associações científicas internacionais.

 

Atualmente o acervo do Portal de Periódicos da Capes é composto por:

130 bases de dados de referências e resumos; 96 bases de dados de texto completo, mais de 35 mil periódicos; 28 bases de dados de livros eletrônicos, mais de 153 mil títulos 33 obras de referência (enciclopédias, dicionários, compêndios etc.); 67 bases de teses e dissertações; 57 bases de estatísticas; 11 bases de dados de patentes; 2 bases de normas técnicas.

 

Acesse o Portal de Periódicos no endereço http://www.periodicos.capes.gov.br/ e explore todo o conteúdo disponível.

 

 

IV SIMPÓSIO DE PLANTAS MEDICINAIS DO VALE DO SÃO FRANCISCO.

A Universidade Federal do Vale do São Francisco (UNIVASF) promoverá, no período de 18 a 21 de setembro de 2013, o IV SIMPÓSIO DE PLANTAS MEDICINAIS DO VALE DO SÃO FRANCISCO. 

Este evento é voltado para estudantes, jovens cientistas, pesquisadores, profissionais de saúde, bem como para a população que tem interesse em plantas medicinais e fitoterapia.

O objetivo do evento é discutir propostas de aproveitamento do potencial químico e farmacológico da biodiversidade da região do Vale do São Francisco. Para isso, pesquisadores de diversas instituições no país estão sendo convidados para trazer novos conhecimentos nas diversas áreas relacionadas ao estudo de plantas medicinais. O Simpósio será realizado no Complexo Multieventos, no campus da UNIVASF em Juazeiro-BA.

A submissão de trabalhos científicos poderá ser feita até o dia 19 de julho de 2013. Até essa data, a inscrição para estudantes de graduação custará R$ 65,00 com direito a um mini curso.

As inscrições poderão ser feitas também através do site www.plamevasf.com


Solicitamos, gentilmente, divulgação do evento. Segue em anexo um cartaz para divulgação e a programação científica do evento.

Estamos esperando por vocês!

Maiores informações no site: http://www.plamevasf.univasf.edu.br/

Convite GP

Convite GP

Semana de IC Curso de Farmácia

Prezados(as) Pós-Graduandos(as)

As palestras com destaque na programação abaixo (4 palestras) serão computadas como atividade de Seminários para o PPGF.

ATENÇÃO: Assine a lista de presença específica que estará na entrada do auditório.

Local: auditório do Curso de Farmácia (Bloco E1)

Planta Medica Issue 9 2013 now available

 

Dear Colleague, Welcome to the 9th issue of the Planta Medica Newsletter 2013! In this Planta Medica issue I have selected a review, a pharmacological and an analytical study to be highlighted. Harlev et al. have reviewed natural products originating from plants of the Cactaceae family with cancer preventive or curative properties, a still largely unexploited area of research. Hot flushes are the most common and distressing symptom accompanying the menopausal transition in women; finding an alternative treatment is of importance as increasing numbers of women become reluctant to rely on classical hormone replacement therapy. Rahte et al. have investigated the mechanism of action and the active principles of Salvia officinalis against hot flushes. It is suggested that common and ubiquitous estrogenic flavonoids are involved in its anti-hot flush effect.

 

Finally, Zeng et al. have developed and validated a quantitative liquid chromatography–electrospray ionization–mass spectrometric method for the simultaneous determination of 18 bioactive constituents in Tripterygium wilfordii, which is widely distributed in southern China. The stem and root of T. wilfordii, known as "Leigongteng" (in Chinese "thunder god vine"), are used in traditional Chinese medicine, and play a significant role in the clinical treatment of rheumatoid arthritis in China. It is my pleasure to offer you free access to these publications!

 

Sincerely, Luc Pieters Planta Medica, Editor-in-Chief

 

CONTENTS ·         Cancer Preventive and Curative Attributes of Plants of the Cactaceae Family: A Review ·         Salvia officinalis for Hot Flushes: Towards Determination of Mechanism of Activity and Active Principles ·         Simultaneous Quantification of 18 Bioactive Constituents in Tripterygium wilfordii Using Liquid Chromatography-Electrospray Ionization-Mass Spectrometry ·         Table of Contents: Issue 9, June 2013

 

Cancer Preventive and Curative Attributes of Plants of the Cactaceae Family: A Review (FREE ACCESS) Eli Harlev, Eviatar Nevo, Elaine Solowey, Anupam Bishayee

 

The ever-increasing occurrence of cancer and the severe side effects and limited efficacy of current cancer chemotherapy based on chemical drugs shift the attention toward drugs of plant origin. The Cactaceae family comprises more than 1500 species, but until recently only a few of them have been tested for their chemopreventive and anticancer attributes, leaving a wide unexplored area still waiting for researchers to be investigated.

 

Considering this fact, and also the promising results obtained with the relatively few plants of this family already tested, it should justly be expected that some plants of the Cactaceae family yet unexplored might possess outstanding anticancer attributes, exceeding those displayed by the plants already tested. This review presents in vitro and in vivo experimental evidence on cancer chemopreventive and therapeutic potential of bioactive phytoconstituents and extracts derived from cactus plants. It also examines the underlying biochemical and molecular mechanisms involved in the antineoplastic effects of plants of the Cactaceae family. Current limitation and future directions of research towards effective use of cacti to develop efficient and side effect-free future cancer-preventive and anticancer drugs are also discussed. Read more

 

top   Salvia officinalis for Hot Flushes: Towards Determination of Mechanism of Activity and Active Principles (FREE ACCESS) Sinikka Rahte, Richard Evans, Philippe J. Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemir

 

Herbal medicinal products are commonly used in alternative treatment of menopausal hot flushes. In a recent clinical study, Salvia officinalis tincture was found to reduce hot flush frequency and intensity. The aim of the current study was the investigation of the mechanism(s) responsible for the anti-hot flush activity of S. officinalis and determination of its active principle(s). The 66% ethanolic tincture, as well as the n-hexane, CHCl3, and aqueous ethanolic subextracts obtained from the

 

 

tincture were studied in vitro for two of the most relevant activities, estrogenicity and selective serotonin reuptake inhibition. Because of an increased risk of menopausal women to suffer from Alzheimer's disease, an in vitro acetylcholinesterase inhibition assay was also employed. No activity was observed in the selective serotonin reuptake inhibition or the acetylcholinesterase inhibition assays at the highest test concentrations. The tincture showed no estrogenic effects whereas the aqueous ethanolic subextract exhibited estrogenicity in the ERLUX assay with an EC50 value of 64 µg/mL. Estrogenic activity-guided fractionation of the aqueous ethanolic subextract by a combination of reverse-phase vacuum liquid chromatography and gel chromatography identified luteolin-7-O-glucuronide (EC50 129 µg/mL) as the active component of the vacuum liquid chromatography fraction 4 (EC50 69 µg/mL). Luteolin-7-O-glucoside was identified as the putative estrogenic principle of the most potent minor fraction (EC50 0.7 µg/mL) obtained from the initial vacuum liquid chromatography fraction 7 (EC50 3 µg/mL). This study suggests the involvement of common and ubiquitous estrogenic flavonoids in the anti-hot flush effect of Salvia officinalis, a safe and commonly used herbal medicinal product during the menopause. Read more

 

top   Simultaneous Quantification of 18 Bioactive Constituents in Tripterygium wilfordii Using Liquid Chromatography-Electrospray Ionization-Mass Spectrometry (FREE ACCESS) Feng Zeng, Wei Wang, Shuhong Guan, Chunru Cheng, Min Yang, Bharathi Avula, Ikhlas A. Khan, De-an Guo

 

A liquid chromatography – electrospray ionization – mass spectrometry method with multiple reaction monitoring was established for simultaneous quantification of 18 bioactive constituents from the stem and root of Tripterygium wilfordii Hook. f. collected from different places in China and various commercial preparations.

 

The chromatographic separations were achieved on an Agilent Poroshell SB–C18 column (150 × 4.6 mm, 3.5 µm) with gradient elution using acetonitrile and 0.03% formic acid aqueous solution in 45 min. Detection was performed in the positive ionization mode by monitoring the precursor–product combination. The validation of the method included tests of linearity, sensitivity, precision, repeatability, stability, and accuracy. All calibration curves showed good linearity (r > 0.9990) within the test range. The established method showed good precision and accuracy with intraday and interday variations of 2–5% and 1–4%, respectively, and recoveries of 95.5–104.5%. Read more

 

top   Table of Contents: Issue 9, June 2013 Reviews Original Papers FREE ARTICLE: Cancer Preventive and Curative Attributes of Plants of the Cactaceae Family: A Review Eli Harlev, Eviatar Nevo, Elaine Solowey, Anupam Bishayee Abstract | HTML | PDF Biological and Pharmacological Activity Original Papers Anxiolytic Action of Pterostilbene: Involvement of Hippocampal ERK Phosphorylation Md. Al Rahim, Agnes M. Rimando Kalpten Silistreli, Abir T. El-Alfy Abstract | HTML | PDF Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects Wei-ping Zhang, Xiao-jun Bai, Xiao-pu Zheng, Xiao-lu Xie, Zu-yi Yuan Abstract | HTML | PDF Wound-Healing Potential of the Root Extract of Albizzia lebbeck Apurva Joshi, Nidhi Sengar, Satyendra K. Prasad, Raj Kumar Goel, Akanksha Singh, Siva Hemalatha Abstract | HTML | PDF Salvia miltiorrhiza (Danshen) Injection Ameliorates Iron Overload-Induced Cardiac Damage in Mice Jian-ping Zhang, Yuan-yuan Zhang, Ying Zhang, Yong-gang Gao, Juan-juan Ma, Na Wang, Jiang-yan Wang, Yun Xie, Feng-hua Zhang, Li Chu Abstract | HTML | PDF FREE ARTICLE: Salvia officinalis for Hot Flushes: Towards Determination of Mechanism of Activity and Active Principles Sinikka Rahte, Richard Evans, Philippe J. Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemir Abstract | HTML | PDF Hepatoprotective Phenolic Glycosides from Gymnema tingens Jin Tian, Qin-Ge Ma, Jian-Bo Yang, Ai-Guo Wang, Teng-Fei Ji, Yan-Gai Wang, Ya-Lun Su Abstract | HTML | PDF Protective Effects of α-Tocopherol and Ascorbic Acid against Cardol-Induced Cell Death and Reactive Oxygen Species Generation in Staphylococcus aureus Wakae Murata, Toshio Tanaka, Isao Kubo, Ken-ichi Fujita Abstract | HTML | PDF Arsenic Trioxide-Enhanced, Matrine-Induced Apoptosis in Multiple Myeloma Cell Lines Qinghong Yu, Binhai Chen, Xiang Zhang, WenBin Qian, Baodong Ye, Yuhong Zhou Abstract | HTML | PDF Inhibition of Lipopolysaccharide-Induced iNOS and COX-2 Expression by Indole Alkaloid, 3-(Hydroxymethyl)-6,7-Dihydroindolo[2,3-a]Quinolizin-(12H)-one, via NF-κB Inactivation in RAW 264.7 Macrophages Feng Zhao, Lei Chen, Menglin Zhang, Chenchen Bi, Lichun Li, Qingzhen Zhang, Cuicui Shi, Miao Li, Songsong Zhou, Linghua Kong Abstract | HTML | PDF Natural Product Chemistry Letters Steroidal Glycosides from Reineckia carnea herba and Their Antitussive Activity Na Han, Ling Li Chen, Yao Wang, Rui Xue, Li Bo Zou, Fang Liu, Jun Yin Abstract | HTML | PDF Three New Xanthones from the Resin of Garcinia hanburyi Yun-Xia Deng, Tao Guo, Zhi-Yu Shao, Hui Xie, Sheng-Li Pan Abstract | HTML | PDF Analytical Studies Original Papers FREE ARTICLE: Simultaneous Quantification of 18 Bioactive Constituents in Tripterygium wilfordii Using Liquid Chromatography-Electrospray Ionization-Mass Spectrometry Feng Zeng, Wei Wang, Shuhong Guan, Chunru Cheng, Min Yang, Bharathi Avula, Ikhlas A. Khan, De-an Guo Abstract | HTML | PDF Click here to see the full table of contents for this issue.   About this Journal Editor in Chief: Luc Pieters, Belgium Planta Medica is one of the leading international journals in the field of medicinal plants and natural products with original research papers, letters, rapid communications, reviews, minireviews and perspectives from researchers worldwide. Authors, please submit your manuscripts electronically to: http://mc.manuscriptcentral.com/plamed. For further information about Planta Medica, please visit www.thieme.de/plantamedica   © Thieme Medical Publishers, Inc. 2008-2013, All Rights Reserved 333 7th Ave., New York, NY Americas customerservice@thieme.com f:1-212-947-1112 p:1-212-760-0888 Europe, Asia, Africa, Australia customerservice@thieme.de f: +49-711-8931-410 Impressum   This email was sent to cechinel@univali.br. If you are no longer interested you can unsubscribe instantly.

I Simpósio Iberoamericano de Investigação em Câncer

É com enorme satisfação que anunciamos, como atividade formativa da Rede RIBECANCER/CYTED/CNPq (www.ribecancer.com.br) a realização do I Simpósio Iberoamericano de Investigação em Câncer que irá ocorrer em Campinas-SP dias 24 e 25 de Setembro, 2013.

Acesse o site e conheça a Programação e maiores detalhes:

http://2013siic.wix.com/siic2013

Cordialmente,

Prof. João Ernesto de Carvalho (CPQBA/UNICAMP)

Coordenador do Simpósio

Prof. Valdir Cechinel Filho (UNIVALI)

Coordenador da Rede RIBECANCER